Magentiq Eye MAGENTIQ-COLO™ - AI COLONOSCOPY ASSISTANCE Real-Time Polyp Detection for Colonoscopy

Magentiq Eye has developed MAGENTIQ-COLO™, a groundbreaking AI COLONOSCOPY ASSISTANCE system that transforms colonoscopy effectiveness through real-time computer vision analysis. This FDA 510(k)-cleared and CE-marked medical device addresses one of gastroenterology’s most critical challenges: missed polyps during colonoscopy that can progress to colorectal cancer—the third leading cause of cancer death worldwide.

The Clinical Challenge: Missed Polyps

Colonoscopy remains the gold standard for colorectal cancer screening and prevention, enabling detection and removal of precancerous polyps before they become malignant. However, studies reveal concerning miss rates:

• 25-30% of polyps are missed during routine colonoscopy
• Adenoma Detection Rate (ADR) varies significantly between endoscopists (15-50%)
• Flat and diminutive polyps are particularly challenging to identify
• Human factors—fatigue, distraction, variable skill levels—contribute to inconsistent detection

Each 1% increase in ADR correlates with a 3% reduction in interval colorectal cancer risk. Missing adenomas during colonoscopy directly translates to preventable cancers and deaths. MAGENTIQ-COLO™ addresses this life-threatening gap through intelligent, tireless AI assistance.

How MAGENTIQ-COLO™ Works

Real-Time Computer Vision Analysis

MAGENTIQ-COLO™ integrates seamlessly with existing colonoscopy equipment, analyzing video feeds in real-time without workflow disruption. The AI system:

• Processes live video at high frame rates, examining every millimeter of colon mucosa as the endoscope advances and withdraws
• Detects suspicious lesions using deep learning models trained on thousands of annotated colonoscopy videos
• Identifies diverse polyp types: sessile, pedunculated, flat, diminutive adenomas across various morphologies
• Works across lighting conditions and viewing angles, maintaining consistent performance throughout procedures

Instant Visual Alerts

When the AI detects a potential polyp, it immediately generates visual indicators on the endoscopist’s screen:

• Bounding boxes highlight suspicious areas in real-time
• Audio alerts (optional) notify the physician without requiring visual attention shift
• Color-coded confidence levels indicate detection certainty
• Non-intrusive design avoids disrupting physician workflow or decision-making autonomy

The system functions as an intelligent second observer, drawing attention to lesions that might otherwise be overlooked during the complex visual search task of colonoscopy.

Continuous Learning & Optimization

MAGENTIQ-COLO™ continuously evolves through machine learning refinement based on real-world colonoscopy data, improving detection accuracy across diverse patient populations, equipment types, and clinical settings.

Clinical Performance: Validated Excellence

Landmark Lancet Digital Health Study

A rigorous international multicenter randomized controlled trial published in Lancet Digital Health demonstrated MAGENTIQ-COLO™’s transformative impact:

• 7% absolute increase in Adenoma Detection Rate—a clinically significant improvement representing hundreds of additional cancers prevented per 10,000 screenings
• Significant reduction in missed polyp rates across all endoscopist skill levels
• Consistent benefit across diverse patient demographics and clinical settings

Exceptional Accuracy Metrics

• Sensitivity: 99.6% for polyp detection—virtually eliminating false negatives
• Specificity: 98%—minimizing false positive alerts that could cause unnecessary interventions
• Per-polyp detection rate improvement of 20-30% in real-world implementations
• Enhanced small adenoma detection—the lesions most likely to be missed by human observation alone

These performance metrics position MAGENTIQ-COLO™ among the most accurate AI diagnostic tools across all medical specialties.

Impact Across Endoscopist Experience Levels

Importantly, MAGENTIQ-COLO™ benefits both novice and expert endoscopists:

• Experienced physicians maintain high baseline ADRs while capturing additional missed lesions
• Less experienced endoscopists see substantial ADR improvements, standardizing quality across practice groups
• Training enhancement for fellows and residents through real-time feedback

Clinical Benefits

Cancer Prevention: Each additional adenoma detected and removed represents potential colorectal cancer prevention. With over 15 million colonoscopies performed annually in the US alone, even modest ADR improvements prevent thousands of cancers.

Improved Patient Outcomes: Higher detection rates reduce interval cancers—malignancies appearing between screening colonoscopies due to missed lesions.

Quality Metric Enhancement: ADR is a key colonoscopy quality indicator tracked for accreditation, physician credentialing, and reimbursement. MAGENTIQ-COLO™ helps practices meet and exceed benchmarks.

Reduced Liability Risk: Missed polyps represent significant medicolegal exposure. AI-assisted colonoscopy provides documentation of enhanced diligence and standard-of-care optimization.

Physician Confidence: Real-time AI assistance reduces anxiety about missing lesions, particularly during challenging cases or when fatigued.

Regulatory Validation & Global Adoption

FDA 510(k) Clearance: Rigorous US regulatory approval confirms safety and effectiveness for clinical use.

CE Mark (Europe): European certification enabling deployment across EU healthcare systems.

Clinical Validation: Multiple peer-reviewed publications beyond the Lancet study confirm reproducible benefits across international centers.

Global Implementation: Deployed in leading gastroenterology practices, ambulatory surgery centers, and hospital endoscopy units across North America, Europe, and Israel.

Implementation Considerations

Technical Integration: Compatible with major colonoscopy equipment manufacturers (Olympus, Pentax, Fujifilm). Simple hardware connection with minimal setup requirements.

Workflow Impact: Transparent integration—endoscopists perform procedures normally while AI operates in background. Average procedure time increases less than 1 minute.

Training Requirements: Minimal physician training (typically 15-30 minutes) to understand alert systems and optimize AI utilization.

Cost-Effectiveness: Subscription or per-procedure pricing models. ROI achieved through improved quality metrics, reduced interval cancer liability, and potential enhanced reimbursement for high-quality colonoscopy.

Patient Acceptance: Studies show patients highly value AI-enhanced colonoscopy, viewing it as advanced care and quality indicator.

The Magentiq Eye Difference

Founded in 2014 by Dr. Dror Zur, a computer science and engineering expert, Magentiq Eye has focused exclusively on colonoscopy AI optimization. This specialization delivers:

• Superior accuracy compared to general-purpose medical imaging AI
• Colonoscopy-specific training on thousands of procedure videos
• Continuous improvement through ongoing clinical partnerships
• Physician-centric design developed through extensive endoscopist collaboration

Who Should Adopt MAGENTIQ-COLO™

• Gastroenterology practices seeking quality differentiation and improved outcomes
• Hospital endoscopy units targeting ADR benchmark achievement
• Ambulatory surgery centers enhancing competitive positioning
• Academic medical centers providing trainees with state-of-the-art technology
• Individual endoscopists committed to excellence and cancer prevention

Conclusion

MAGENTIQ-COLO™ represents the evolution of colonoscopy from solely physician-dependent visual examination to AI-augmented precision screening. With proven 7% ADR improvement, 99.6% sensitivity, and validation in top-tier medical journals, Magentiq Eye delivers technology that saves lives through enhanced colorectal cancer prevention.

For gastroenterology practices committed to clinical excellence and patient outcomes, MAGENTIQ-COLO™ offers validated AI assistance that standardizes quality, improves detection, and prevents cancer—the ultimate goal of screening colonoscop